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Striker Mason Greenwood will start the Europa League team game against Astana of Manchester United .
The 17-year-old has made four substitute appearances in the Premier League this year.
England under-21 shield Axel Tuanzebe may start, alongside midfielder Fred and reserve goalkeeper Sergio Romero.
Winger Daniel James misses out after picking up a knock against Leicester.
The 21-year-old Welshman, who has scored three goals in five league matches this year, combines midfielder Paul Pogba, forward Anthony Martial and shield Luke Shaw on the injury list.
But, midfielder Jesse Lingard has recovered from disease and is very likely to be involved.
Greenwood had an impressive summertime for United, scoring in pre-season successes over Inter Milan and Leeds later making his debut in a 2-0 defeat to Arsenal in the Premier League in March.
He will start his first game of the year on Thursday and director Ole Gunnar Solskjaer says he has”matured in the previous six months”.
“He is still very young. I remember the child who just wanted to play with his mates at the under-18s,” explained Solskjaer. “Now he is knocking on the door along with his desire for football has to be increasing.
“I simply don’t wish to put too much stress on him. Mason’s among the top finishers I have seen and I’ve played with a couple of decent ones.
“If you’re 17, 18, 19 years old, another game is obviously the most important one. It isn’t important how many you scored.
“There will probably soon be 11 Astana players living the dream – it’s but one of the biggest games of their livelihood – but I still want it to be a memorable one for our gamers as well.”
Tuanzebe made his debut in a 4-0 win over Wigan in the FA Cup in January 2017 and has produced nine first-team appearances in total for Manchester United.
However he’s played only one moment from the Premier League this season, coming on as a late substitute in Saturday’s narrow 1-0 victory over Leicester.
“It is a part of the process of developing. I recall my glimpses from the first team at 19 – it was not to be then but now I’m 21 and things have started to open up more. I know just where I want to be going,” explained Tuanzebe.
Solskjaer added:”In case you do not throw them , you don’t know exactly what you’ve obtained. I don’t see any method of doing this.
“I’ve always done it wherever I’ve been, that is my belief as a mentor, to provide an opportunity, a chance.”
Despite attaining the quarter-finals of the Champions League last year, United entered the Europa League after a sixth-place finish from the Premier League.
They have never failed to go beyond the group stages and won this competition.
It is the very first time they come up from Kazakh winners Astana, who are competing in the Europa League for the fourth successive season.
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